What the FDA labels say about taking them together
Elagolix and midazolam
Elagolix's FDA label of December 19, 2025 names midazolam in its drug interactions section; the midazolam labels PlainMeds reads (4) do not name elagolix. The elagolix label: “Consider increasing the dose of midazolam by no more than 2-fold and individualize midazolam therapy based on the patient’s response.”
Check it at the source: the elagolix FDA label on DailyMed (effective December 19, 2025, AbbVie Inc.); the midazolam FDA label on DailyMed (effective January 1, 2024, Fresenius Kabi USA, LLC).
What does the elagolix label say about midazolam?
Elagolix label, drug interactionsConcomitant Drug Class/Drug Name: Benzodiazepines: oral midazolam; Effect on Plasma Exposure of Concomitant Drug: ↓ midazolam; Clinical Recommendations: Consider increasing the dose of midazolam by no more than 2-fold and individualize midazolam therapy based on the patient’s response.
Source: FDA drug label (Orilissa), AbbVie Inc., effective December 19, 2025 (SPL set a86757b3-09c5-fd3b-1223-244e94f50a66), via openFDA; the full label on DailyMed
What does the midazolam label say about elagolix?
Midazolam's label (effective January 1, 2024) and its 3 other brand-application labels do not name elagolix in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Midazolam), Fresenius Kabi USA, LLC, effective January 1, 2024 (SPL set 1cc9ba6e-fa1b-405e-9de8-720c567b2a73), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Elagolix | Midazolam | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $43.81 per tablet 150 mg tablet | $0.233 per mL 2 mg/2 mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once