What the FDA labels say about taking them together
Elagolix and levonorgestrel
Elagolix's FDA label of December 19, 2025 names levonorgestrel in its drug interactions section; the levonorgestrel labels PlainMeds reads (4) do not name elagolix. The elagolix label: “Increase in Estrogen Exposure and Potential Associated Increased Risks When ORILISSA 200 mg Twice Daily is Taken With Combined Hormonal Contraceptives Co-administration of a combined oral contraceptive (COC) following …”
Check it at the source: the elagolix FDA label on DailyMed (effective December 19, 2025, AbbVie Inc.); the levonorgestrel FDA label on DailyMed (effective January 31, 2023, Foundation Consumer Healthcare LLC).
What does the elagolix label say about levonorgestrel?
Elagolix label, drug interactionsConcomitant Drug Class/Drug Name: Combined hormonal contraceptives: oral ethinyl estradiol/levonorgestrel; Effect on Plasma Exposure of Concomitant Drug: ↑ethinyl estradiol ↓levonorgestrel; Clinical Recommendations: Advise women to use effective non-hormonal contraception during treatment with ORILISSA and for 28 days after discontinuing ORILISSA.
Elagolix label, warnings and precautionsIncrease in Estrogen Exposure and Potential Associated Increased Risks When ORILISSA 200 mg Twice Daily is Taken With Combined Hormonal Contraceptives Co-administration of a combined oral contraceptive (COC) (containing 20 mcg ethinyl estradiol/0.1 mg levonorgestrel) following administration of ORILISSA 200 mg twice daily for 14 days increases the plasma ethinyl estradiol concentration by 2.2-fold compared to this COC alone.
Source: FDA drug label (Orilissa), AbbVie Inc., effective December 19, 2025 (SPL set a86757b3-09c5-fd3b-1223-244e94f50a66), via openFDA; the full label on DailyMed
What does the levonorgestrel label say about elagolix?
Levonorgestrel's label (effective January 31, 2023) and its 3 other brand-application labels do not name elagolix in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Plan B One-Step), Foundation Consumer Healthcare LLC, effective January 31, 2023 (SPL set 6ce6b40e-14ac-47bd-a648-ddf9e452e559), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Elagolix | Levonorgestrel | |
|---|---|---|
| Labeled for | n/a | Birth control |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $43.81 per tablet 150 mg tablet | $6.33 per tablet 1.5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once