What the FDA labels say about taking them together
Elafibranor and pioglitazone
Elafibranor's FDA label of August 11, 2026 names pioglitazone in its drug interactions section; the pioglitazone label PlainMeds reads does not name elafibranor. The elafibranor label: “Clinical impact; Co-administration of IQIRVO with PPAR-gamma agonists may increase risk of liver injury.”
Check it at the source: the elafibranor FDA label on DailyMed (effective August 11, 2026, Ipsen Biopharmaceuticals, Inc.); the pioglitazone FDA label on DailyMed (effective March 28, 2025, Takeda Pharmaceuticals America, Inc.).
What does the elafibranor label say about pioglitazone?
Elafibranor label, drug interactionsClinical impact; Co-administration of IQIRVO with PPAR-gamma agonists (e.g., pioglitazone, rosiglitazone) may increase risk of liver injury.
Elafibranor label, warnings and precautionsPatients concomitantly taking PPAR-alpha agonists (e.g., fenofibrate, fenofibric acid) and/or PPAR-gamma agonists (e.g., pioglitazone, rosiglitazone) may have an increased risk of liver injury.
Source: FDA drug label (IQIRVO), Ipsen Biopharmaceuticals, Inc., effective August 11, 2026 (SPL set d78aa14f-6ec1-4b1d-a4ae-e48658137a25), via openFDA; the full label on DailyMed
What does the pioglitazone label say about elafibranor?
Pioglitazone's label (effective March 28, 2025) does not name elafibranor in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Actos), Takeda Pharmaceuticals America, Inc., effective March 28, 2025 (SPL set d2ddc491-88a9-4063-9150-443b4fa4330c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Elafibranor | Pioglitazone | |
|---|---|---|
| Labeled for | n/a | Type 2 diabetes |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0675 per tablet 15 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once