What the FDA labels say about taking them together
Efbemalenograstim alfa and pegfilgrastim
Efbemalenograstim alfa's FDA label of May 19, 2026 names pegfilgrastim in its contraindications section; the pegfilgrastim labels PlainMeds reads (4) do not name efbemalenograstim alfa. The efbemalenograstim alfa label: “CONTRAINDICATIONS RYZNEUTA is contraindicated in patients with a history of serious allergic reactions to granulocyte stimulating factors such as efbemalenograstim alfa-vuxw, pegfilgrastim, or filgrastim products.”
Check it at the source: the efbemalenograstim alfa FDA label on DailyMed (effective May 19, 2026); the pegfilgrastim FDA label on DailyMed (effective August 10, 2026, Amgen, Inc).
What does the efbemalenograstim alfa label say about pegfilgrastim?
Efbemalenograstim alfa label, contraindicationsCONTRAINDICATIONS RYZNEUTA is contraindicated in patients with a history of serious allergic reactions to granulocyte stimulating factors such as efbemalenograstim alfa-vuxw, pegfilgrastim, or filgrastim products [see Warnings and Precautions ( 5.3 )].
Efbemalenograstim alfa label, warningsRYZNEUTA is contraindicated in patients with a history of serious allergic reactions to RYZNEUTA or other rhG-CSF products such as pegfilgrastim, eflapegrastim or filgrastim products.
Source: FDA drug label (RYZNEUTA), Acrotech Biopharma Inc, effective May 19, 2026 (SPL set 290ed754-758c-9cae-e063-6294a90ae68b), via openFDA; the full label on DailyMed
What does the pegfilgrastim label say about efbemalenograstim alfa?
Pegfilgrastim's label (effective August 10, 2026) and its 3 other brand-application labels do not name efbemalenograstim alfa in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Neulasta), Amgen, Inc, effective August 10, 2026 (SPL set fdfe5d72-6b80-435a-afa4-c5d74dd852ce), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Efbemalenograstim alfa | Pegfilgrastim | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $3,369.51 per mL 6 mg/0.6 mL syringe |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once