What the FDA labels say about taking them together
Efavirenz/emtricitabine/tenofovir disoproxil and raltegravir
Efavirenz/emtricitabine/tenofovir disoproxil's FDA label of July 28, 2025 names raltegravir in its drug interactions section; the raltegravir labels PlainMeds reads (2) do not name efavirenz/emtricitabine/tenofovir disoproxil.
Check it at the source: the efavirenz/emtricitabine/tenofovir disoproxil FDA label on DailyMed (effective July 28, 2025, Laurus Labs Limited); the raltegravir FDA label on DailyMed (effective October 18, 2024, Merck Sharp & Dohme LLC).
What does the efavirenz/emtricitabine/tenofovir disoproxil label say about raltegravir?
Efavirenz/emtricitabine/tenofovir disoproxil label, drug interactionsConcomitant Drug Class/Drug Name: Integrase strand transfer inhibitor: raltegravir; Effect: ↓ raltegravir; Clinical Comment: The clinical significance of this interaction has not been directly assessed.
Source: FDA drug label (Efavirenz, emtricitabine and tenofovir disoproxil fumarate), Laurus Labs Limited, effective July 28, 2025 (SPL set aca22076-f435-4533-9fcf-566b0734c313), via openFDA; the full label on DailyMed
What does the raltegravir label say about efavirenz/emtricitabine/tenofovir disoproxil?
Raltegravir's label (effective October 18, 2024) and its 1 other brand-application label do not name efavirenz/emtricitabine/tenofovir disoproxil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ISENTRESS), Merck Sharp & Dohme LLC, effective October 18, 2024 (SPL set 89a5ec53-d956-4329-8004-0f40f51c88a3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Efavirenz/emtricitabine/tenofovir disoproxil | Raltegravir | |
|---|---|---|
| Labeled for | HIV | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.12 per tablet 600-200-300 mg tablet | $34.54 per tablet 400 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once