What the FDA labels say about taking them together
Efavirenz and pravastatin
Efavirenz's FDA label of March 31, 2024 names pravastatin in its drug interactions section; the pravastatin label PlainMeds reads does not name efavirenz. The efavirenz label: “Plasma concentrations of atorvastatin, pravastatin and simvastatin decreased. Consult the full prescribing information for the HMG-CoA reductase inhibitor for guidance on individualizing the dose.”
Check it at the source: the efavirenz FDA label on DailyMed (effective March 31, 2024, Cipla USA Inc.); the pravastatin FDA label on DailyMed (effective July 31, 2026, Apotex Corp.).
What does the efavirenz label say about pravastatin?
Efavirenz label, drug interactionsConcomitant Drug Class/Drug Name: HMG-CoA reductase inhibitors: Atorvastatin Pravastatin Simvastatin; Effect: ↓ atorvastatin * ↓ pravastatin * ↓ simvastatin *; Clinical Comment: Plasma concentrations of atorvastatin, pravastatin and simvastatin decreased. Consult the full prescribing information for the HMG-CoA reductase inhibitor for guidance on individualizing the dose.
Source: FDA drug label (Efavirenz), Cipla USA Inc., effective March 31, 2024 (SPL set 92603fa5-7a2c-4bfb-9a70-aadb4fba952c), via openFDA; the full label on DailyMed
What does the pravastatin label say about efavirenz?
Pravastatin's label (effective July 31, 2026) does not name efavirenz in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PRAVASTATIN SODIUM), Apotex Corp., effective July 31, 2026 (SPL set dcf45e4f-b46e-6fbb-b67a-2ff619ab1780), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Efavirenz | Pravastatin | |
|---|---|---|
| Labeled for | HIV | Heart attack and coronary artery disease, High cholesterol, High triglycerides |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.28 per tablet 600 mg tablet | $0.058 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once