What the FDA labels say about taking them together
Efavirenz and nevirapine
Nevirapine's FDA label of July 15, 2026 names efavirenz in its drug interactions section; the efavirenz label PlainMeds reads does not name nevirapine. The nevirapine label: “Co-administration of nevirapine and efavirenz is not recommended as this combination has been associated with an increase in adverse reactions and no improvement in efficacy.”
Check it at the source: the efavirenz FDA label on DailyMed (effective March 31, 2024, Cipla USA Inc.); the nevirapine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.).
What does the efavirenz label say about nevirapine?
Efavirenz's label (effective March 31, 2024) does not name nevirapine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Efavirenz), Cipla USA Inc., effective March 31, 2024 (SPL set 92603fa5-7a2c-4bfb-9a70-aadb4fba952c), via openFDA; the full label on DailyMed
What does the nevirapine label say about efavirenz?
Nevirapine label, drug interactionsDrug Name: Efavirenz; Effect on Concentration of Nevirapine or Concomitant Drug: ↓ Efavirenz; Clinical Comment: The appropriate doses of these combinations with respect to safety and efficacy have not been established.
Nevirapine label, warnings and precautionsCo-administration of nevirapine and efavirenz is not recommended as this combination has been associated with an increase in adverse reactions and no improvement in efficacy.
Source: FDA drug label (Nevirapine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set c6e93829-7024-48f6-8023-da6ff27dfc0a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Efavirenz | Nevirapine | |
|---|---|---|
| Labeled for | HIV | HIV |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.28 per tablet 600 mg tablet | $0.147 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once