What the FDA labels say about taking them together
Efavirenz and maraviroc
Efavirenz's FDA label of March 31, 2024 names maraviroc in its drug interactions section, and maraviroc's label names efavirenz too. The maraviroc label: “Coadministration with CYP3A inducers, including efavirenz, may decrease the concentration of SELZENTRY.”
Check it at the source: the efavirenz FDA label on DailyMed (effective March 31, 2024, Cipla USA Inc.); the maraviroc FDA label on DailyMed (effective September 26, 2022, ViiV Healthcare Company).
What does the efavirenz label say about maraviroc?
Efavirenz label, drug interactionsConcomitant Drug Class/Drug Name: CCR5 co-receptor antagonist: Maraviroc; Effect: ↓ maraviroc *; Clinical Comment: Refer to the full prescribing information for maraviroc for guidance on coadministration with efavirenz.
Source: FDA drug label (Efavirenz), Cipla USA Inc., effective March 31, 2024 (SPL set 92603fa5-7a2c-4bfb-9a70-aadb4fba952c), via openFDA; the full label on DailyMed
What does the maraviroc label say about efavirenz?
Maraviroc label, drug interactionsCoadministration with CYP3A inducers, including efavirenz, may decrease the concentration of SELZENTRY.
Maraviroc label, warnings and precautionsIn the Phase 2b/3 trial in treatment‑naive adult subjects, 3 subjects (0.8%) who received SELZENTRY had events related to ischemic heart disease and 5 subjects (1.4%) who received efavirenz had such events (total exposure 506 and 508 patient‑years for SELZENTRY and efavirenz, respectively).
Source: FDA drug label (SELZENTRY), ViiV Healthcare Company, effective September 26, 2022 (SPL set 46f30ac5-c96b-429e-976d-8c5ee1c0761b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Efavirenz | Maraviroc | |
|---|---|---|
| Labeled for | HIV | HIV |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.28 per tablet 600 mg tablet | $9.15 per tablet 150 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once