What the FDA labels say about taking them together
Efavirenz and itraconazole
Efavirenz's FDA label of March 31, 2024 names itraconazole in its drug interactions section, and itraconazole's label names efavirenz too. The efavirenz label: “… Consider alternative antifungal treatment because no dose recommendation for itraconazole can be made. Consider alternative antifungal treatment because no dose recommendation for ketoconazole can be made. …”
Check it at the source: the efavirenz FDA label on DailyMed (effective March 31, 2024, Cipla USA Inc.); the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.).
What does the efavirenz label say about itraconazole?
Efavirenz label, drug interactionsConcomitant Drug Class/Drug Name: Antifungals: Voriconazole Itraconazole Ketoconazole Posaconazole; Effect: ↓ voriconazole * ↑ efavirenz * ↓ itraconazole * ↓ hydroxy itraconazole * ↓ ketoconazole ↓ posaconazole *; Clinical Comment: Efavirenz and voriconazole should not be coadministered at standard doses. When voriconazole is coadministered with efavirenz, voriconazole maintenance dose should be increased to 400 mg every 12 hours and efavirenz dose should be decreased to 300 mg once daily using the capsule formulation. Efavirenz tablets must not be broken. [see Dosage and Administration () and Clinical Pharmacology (, and)]. …
Source: FDA drug label (Efavirenz), Cipla USA Inc., effective March 31, 2024 (SPL set 92603fa5-7a2c-4bfb-9a70-aadb4fba952c), via openFDA; the full label on DailyMed
What does the itraconazole label say about efavirenz?
Itraconazole label, drug interactionsAntivirals Efavirenz Nevirapine Not recommended 2 weeks before and during SPORANOX ® treatment.
Source: FDA drug label (Tolsura, NDA208901), Mayne Pharma Commercial LLC, effective April 23, 2025 (SPL set 306352d1-9d5a-49ad-b72d-893b99546861), via openFDA
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Efavirenz | Itraconazole | |
|---|---|---|
| Labeled for | HIV | Fungal infections |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.28 per tablet 600 mg tablet | $0.910 per capsule 100 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once