What the FDA labels say about taking them together
Edoxaban and lenacapavir
Lenacapavir's FDA label of August 27, 2026 names edoxaban in its drug interactions section; the edoxaban label PlainMeds reads does not name lenacapavir.
Check it at the source: the edoxaban FDA label on DailyMed (effective July 10, 2025, Daiichi Sankyo Inc.); the lenacapavir FDA label on DailyMed (effective August 27, 2026, Gilead Sciences, Inc.).
What does the edoxaban label say about lenacapavir?
Edoxaban's label (effective July 10, 2025) does not name lenacapavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (SAVAYSA), Daiichi Sankyo Inc., effective July 10, 2025 (SPL set e77d3400-56ad-11e3-949a-0800200c9a66), via openFDA; the full label on DailyMed
What does the lenacapavir label say about edoxaban?
Lenacapavir label, drug interactionsConcomitant Drug Class/Drug Name: Anticoagulants: Direct Oral Anticoagulants (DOACs) rivaroxaban dabigatran edoxaban; Effect on Concentration ↑ = Increase, ↓ = Decrease.: ↑ DOAC; Clinical Comment: Refer to the DOAC prescribing information for concomitant administration with moderate CYP3A inhibitors and/or P-gp inhibitors.
Source: FDA drug label (Sunlenca), Gilead Sciences, Inc., effective August 27, 2026 (SPL set e5652804-29c4-40d7-aeb2-0142ed2a7b5b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Edoxaban | Lenacapavir | |
|---|---|---|
| Labeled for | Atrial fibrillation, Stroke prevention, Blood clots (DVT and PE) | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $15.51 per tablet 60 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once