What the FDA labels say about taking them together
Duloxetine and teriflunomide
Teriflunomide's FDA label of February 20, 2026 names duloxetine in its drug interactions section; the duloxetine labels PlainMeds reads (2) do not name teriflunomide. The teriflunomide label: “In patients taking AUBAGIO, exposure of drugs metabolized by CYP1A2 may be reduced.”
Check it at the source: the duloxetine FDA label on DailyMed (effective May 14, 2024, SUN PHARMACEUTICAL INDUSTRIES, INC.); the teriflunomide FDA label on DailyMed (effective February 20, 2026, Genzyme Corporation).
What does the duloxetine label say about teriflunomide?
Duloxetine's label (effective May 14, 2024) and its 1 other brand-application label do not name teriflunomide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (DRIZALMA SPRINKLE), SUN PHARMACEUTICAL INDUSTRIES, INC., effective May 14, 2024 (SPL set b41423b8-dfec-4d79-ba3c-e43a87803d85), via openFDA; the full label on DailyMed
What does the teriflunomide label say about duloxetine?
Teriflunomide label, drug interactionsIn patients taking AUBAGIO, exposure of drugs metabolized by CYP1A2 (e.g., alosetron, duloxetine, theophylline, tizanidine) may be reduced.
Source: FDA drug label (Aubagio), NDA202992 (Sanofi Aventis Us), as published by Genzyme Corporation, effective February 20, 2026 (SPL set 4650d12c-b9c8-4525-b07f-a2d773eca155), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Duloxetine | Teriflunomide | |
|---|---|---|
| Labeled for | Depression, Anxiety, Nerve pain and fibromyalgia, Pain | Multiple sclerosis |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.102 per capsule 30 mg capsule | $0.233 per tablet 14 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once