What the FDA labels say about taking them together
Droxidopa and midodrine
Droxidopa's FDA label of July 1, 2019 names midodrine in its drug interactions section, and midodrine's label names droxidopa too. The midodrine label: “The risk of hypertension increases with concomitant administration of drugs that increase blood pressure.”
Check it at the source: the droxidopa FDA label on DailyMed (effective July 1, 2019, Lundbeck Pharmaceuticals LLC); the midodrine FDA label on DailyMed (effective December 4, 2025, Novugen Pharma (USA) LLC).
What does the droxidopa label say about midodrine?
Droxidopa label, drug interactionsDrugs that Increase Blood Pressure Administering NORTHERA in combination with other agents that increase blood pressure (e.g., norepinephrine, ephedrine, midodrine, and triptans) would be expected to increase the risk for supine hypertension.
Source: FDA drug label (Northera), Lundbeck Pharmaceuticals LLC, effective July 1, 2019 (SPL set 2179f02c-48d7-48eb-8007-5ae43d8d16bc), via openFDA; the full label on DailyMed
What does the midodrine label say about droxidopa?
Midodrine label, drug interactionsThe risk of hypertension increases with concomitant administration of drugs that increase blood pressure (phenylephrine, pseudoephedrine, ephedrine, dihydroergotamine, thyroid hormones, or droxidopa).
Source: FDA drug label (Midodrine Hydrochloride), Novugen Pharma (USA) LLC, effective December 4, 2025 (SPL set 2bf011fe-d114-42a4-93e2-76a993a3ba34), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Droxidopa | Midodrine | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.472 per capsule 100 mg capsule | $0.111 per tablet 5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once