What the FDA labels say about taking them together
Droxidopa and levodopa
Droxidopa's FDA label of July 1, 2019 names levodopa in its warnings and precautions section; the levodopa label PlainMeds reads does not name droxidopa. The droxidopa label: “Observe patients carefully when the dosage of NORTHERA is changed or when concomitant levodopa is reduced abruptly or discontinued, especially if the patient is receiving neuroleptics.”
Check it at the source: the droxidopa FDA label on DailyMed (effective July 1, 2019, Lundbeck Pharmaceuticals LLC); the levodopa FDA label on DailyMed (effective July 20, 2026, Merz Pharmaceuticals, LLC).
What does the droxidopa label say about levodopa?
Droxidopa label, warnings and precautionsObserve patients carefully when the dosage of NORTHERA is changed or when concomitant levodopa is reduced abruptly or discontinued, especially if the patient is receiving neuroleptics.
Source: FDA drug label (Northera), Lundbeck Pharmaceuticals LLC, effective July 1, 2019 (SPL set 2179f02c-48d7-48eb-8007-5ae43d8d16bc), via openFDA; the full label on DailyMed
What does the levodopa label say about droxidopa?
Levodopa's label (effective July 20, 2026) does not name droxidopa in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Inbrija), Merz Pharmaceuticals, LLC, effective July 20, 2026 (SPL set 077c0f39-a3a2-4b2b-a184-09131889dcfb), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Droxidopa | Levodopa | |
|---|---|---|
| Labeled for | n/a | Parkinson's disease |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.472 per capsule 100 mg capsule | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once