What the FDA labels say about taking them together
Droxidopa and ephedrine
Droxidopa's FDA label of July 1, 2019 names ephedrine in its drug interactions section; the ephedrine labels PlainMeds reads (4) do not name droxidopa. The droxidopa label: “Drugs that Increase Blood Pressure Administering NORTHERA in combination with other agents that increase blood pressure would be expected to increase the risk for supine hypertension.”
Check it at the source: the droxidopa FDA label on DailyMed (effective July 1, 2019, Lundbeck Pharmaceuticals LLC); the ephedrine FDA label on DailyMed (effective September 16, 2024, Nexus Pharmaceuticals, LLC).
What does the droxidopa label say about ephedrine?
Droxidopa label, drug interactionsDrugs that Increase Blood Pressure Administering NORTHERA in combination with other agents that increase blood pressure (e.g., norepinephrine, ephedrine, midodrine, and triptans) would be expected to increase the risk for supine hypertension.
Source: FDA drug label (Northera), Lundbeck Pharmaceuticals LLC, effective July 1, 2019 (SPL set 2179f02c-48d7-48eb-8007-5ae43d8d16bc), via openFDA; the full label on DailyMed
What does the ephedrine label say about droxidopa?
Ephedrine's label (effective September 16, 2024) and its 3 other brand-application labels do not name droxidopa in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Emerphed PFS), Nexus Pharmaceuticals, LLC, effective September 16, 2024 (SPL set 14601778-93ac-43ec-b66b-5a942317133f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Droxidopa | Ephedrine | |
|---|---|---|
| Labeled for | n/a | Asthma |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.472 per capsule 100 mg capsule | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once