What the FDA labels say about taking them together
Drospirenone/ethinyl estradiol/levomefolate and primidone
Drospirenone/ethinyl estradiol/levomefolate's FDA label of March 4, 2026 names primidone in its drug interactions section; the primidone label PlainMeds reads does not name drospirenone/ethinyl estradiol/levomefolate. The drospirenone/ethinyl estradiol/levomefolate label: “Drugs on Folates Several drugs have been reported to reduce folate concentrations by inhibition of the dihydrofolate reductase enzyme or by reducing folate absorption (e.g., cholestyramine), or via unknown mechanisms.”
Check it at the source: the drospirenone/ethinyl estradiol/levomefolate FDA label on DailyMed (effective March 4, 2026, Bayer HealthCare Pharmaceuticals Inc.); the primidone FDA label on DailyMed (effective September 10, 2026, Bausch Health US, LLC).
What does the drospirenone/ethinyl estradiol/levomefolate label say about primidone?
Drospirenone/ethinyl estradiol/levomefolate label, drug interactionsDrugs on Folates Several drugs have been reported to reduce folate concentrations by inhibition of the dihydrofolate reductase enzyme (e.g., methotrexate and sulfasalazine) or by reducing folate absorption (e.g., cholestyramine), or via unknown mechanisms (e.g., antiepileptics such as carbamazepine, phenytoin, phenobarbital, primidone and valproic acid).
Source: FDA drug label (Safyral), Bayer HealthCare Pharmaceuticals Inc., effective March 4, 2026 (SPL set 97563516-306a-4e17-9690-edbda49ecd83), via openFDA; the full label on DailyMed
What does the primidone label say about drospirenone/ethinyl estradiol/levomefolate?
Primidone's label (effective September 10, 2026) does not name drospirenone/ethinyl estradiol/levomefolate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Mysoline), NDA009170 (Valeant), as published by Bausch Health US, LLC, effective September 10, 2026 (SPL set af593171-dabb-4ea3-b44c-89ed457b2c46), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Drospirenone/ethinyl estradiol/levomefolate | Primidone | |
|---|---|---|
| Labeled for | Birth control, Acne | Seizures and epilepsy |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.38 per unit 3-0.02-0.451 | $0.0914 per tablet 50 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once