What the FDA labels say about taking them together
Drospirenone/ethinyl estradiol/levomefolate and levonorgestrel
Drospirenone/ethinyl estradiol/levomefolate's FDA label of March 4, 2026 names levonorgestrel in its warnings and precautions section; the levonorgestrel labels PlainMeds reads (4) do not name drospirenone/ethinyl estradiol/levomefolate. The drospirenone/ethinyl estradiol/levomefolate label: “… associated with a higher risk of venous thromboembolism (VTE) than COCs containing levonorgestrel or some other progestins.”
Check it at the source: the drospirenone/ethinyl estradiol/levomefolate FDA label on DailyMed (effective March 4, 2026, Bayer HealthCare Pharmaceuticals Inc.); the levonorgestrel FDA label on DailyMed (effective January 31, 2023, Foundation Consumer Healthcare LLC).
What does the drospirenone/ethinyl estradiol/levomefolate label say about levonorgestrel?
Drospirenone/ethinyl estradiol/levomefolate label, warnings and precautionsStart no earlier than 4 weeks after delivery, in women who are not breastfeeding. ( 5.1 ) COCs containing DRSP may be associated with a higher risk of venous thromboembolism (VTE) than COCs containing levonorgestrel or some other progestins.
Source: FDA drug label (Safyral), Bayer HealthCare Pharmaceuticals Inc., effective March 4, 2026 (SPL set 97563516-306a-4e17-9690-edbda49ecd83), via openFDA; the full label on DailyMed
What does the levonorgestrel label say about drospirenone/ethinyl estradiol/levomefolate?
Levonorgestrel's label (effective January 31, 2023) and its 3 other brand-application labels do not name drospirenone/ethinyl estradiol/levomefolate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Plan B One-Step), Foundation Consumer Healthcare LLC, effective January 31, 2023 (SPL set 6ce6b40e-14ac-47bd-a648-ddf9e452e559), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Drospirenone/ethinyl estradiol/levomefolate | Levonorgestrel | |
|---|---|---|
| Labeled for | Birth control, Acne | Birth control |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.38 per unit 3-0.02-0.451 | $6.33 per tablet 1.5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once