What the FDA labels say about taking them together
Drospirenone/ethinyl estradiol/levomefolate and lamotrigine
Drospirenone/ethinyl estradiol/levomefolate's FDA label of March 4, 2026 names lamotrigine in its drug interactions section; the lamotrigine labels PlainMeds reads (3) do not name drospirenone/ethinyl estradiol/levomefolate. The drospirenone/ethinyl estradiol/levomefolate label: “COCs have been shown to significantly decrease plasma concentrations of lamotrigine, likely due to induction of lamotrigine glucuronidation.”
Check it at the source: the drospirenone/ethinyl estradiol/levomefolate FDA label on DailyMed (effective March 4, 2026, Bayer HealthCare Pharmaceuticals Inc.); the lamotrigine FDA label on DailyMed (effective October 10, 2025).
What does the drospirenone/ethinyl estradiol/levomefolate label say about lamotrigine?
Drospirenone/ethinyl estradiol/levomefolate label, drug interactionsCOCs have been shown to significantly decrease plasma concentrations of lamotrigine, likely due to induction of lamotrigine glucuronidation.
Source: FDA drug label (Safyral), Bayer HealthCare Pharmaceuticals Inc., effective March 4, 2026 (SPL set 97563516-306a-4e17-9690-edbda49ecd83), via openFDA; the full label on DailyMed
What does the lamotrigine label say about drospirenone/ethinyl estradiol/levomefolate?
Lamotrigine's label (effective October 10, 2025) and its 2 other brand-application labels do not name drospirenone/ethinyl estradiol/levomefolate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LAMICTAL), GlaxoSmithKline LLC, effective October 10, 2025 (SPL set d7e3572d-56fe-4727-2bb4-013ccca22678), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Drospirenone/ethinyl estradiol/levomefolate | Lamotrigine | |
|---|---|---|
| Labeled for | Birth control, Acne | Seizures and epilepsy, Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.38 per unit 3-0.02-0.451 | $0.0268 per tablet 25 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once