What the FDA labels say about taking them together
Drospirenone/ethinyl estradiol/levomefolate and fluconazole
Drospirenone/ethinyl estradiol/levomefolate's FDA label of March 4, 2026 names fluconazole in its drug interactions section; the fluconazole labels PlainMeds reads (2) do not name drospirenone/ethinyl estradiol/levomefolate. The drospirenone/ethinyl estradiol/levomefolate label: “Concomitant administration of moderate or strong CYP3A4 inhibitors such as azole antifungals, verapamil, macrolides, diltiazem, and grapefruit juice can increase the plasma concentrations of the estrogen or the …”
Check it at the source: the drospirenone/ethinyl estradiol/levomefolate FDA label on DailyMed (effective March 4, 2026, Bayer HealthCare Pharmaceuticals Inc.); the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the drospirenone/ethinyl estradiol/levomefolate label say about fluconazole?
Drospirenone/ethinyl estradiol/levomefolate label, drug interactionsConcomitant administration of moderate or strong CYP3A4 inhibitors such as azole antifungals (e.g., ketoconazole, itraconazole, voriconazole, fluconazole), verapamil, macrolides (e.g., clarithromycin, erythromycin), diltiazem, and grapefruit juice can increase the plasma concentrations of the estrogen or the progestin or both.
Source: FDA drug label (Safyral), Bayer HealthCare Pharmaceuticals Inc., effective March 4, 2026 (SPL set 97563516-306a-4e17-9690-edbda49ecd83), via openFDA; the full label on DailyMed
What does the fluconazole label say about drospirenone/ethinyl estradiol/levomefolate?
Fluconazole's label (effective April 7, 2026) and its 1 other brand-application label do not name drospirenone/ethinyl estradiol/levomefolate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Drospirenone/ethinyl estradiol/levomefolate | Fluconazole | |
|---|---|---|
| Labeled for | Birth control, Acne | Fungal infections, Urinary tract infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.38 per unit 3-0.02-0.451 | $0.380 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once