What the FDA labels say about taking them together
Drospirenone/ethinyl estradiol and rifampin
Drospirenone/ethinyl estradiol's FDA label of May 29, 2025 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name drospirenone/ethinyl estradiol. The drospirenone/ethinyl estradiol label: “… barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampin, topiramate and products containing St. John's wort.”
Check it at the source: the drospirenone/ethinyl estradiol FDA label on DailyMed (effective May 29, 2025, Bayer HealthCare Pharmaceuticals Inc.); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the drospirenone/ethinyl estradiol label say about rifampin?
Drospirenone/ethinyl estradiol label, drug interactionsSome drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampin, topiramate and products containing St. John's wort.
Source: FDA drug label (Yaz), Bayer HealthCare Pharmaceuticals Inc., effective May 29, 2025 (SPL set 065f33e4-b587-4e66-b896-ca9ab7b7c876), via openFDA; the full label on DailyMed
What does the rifampin label say about drospirenone/ethinyl estradiol?
Rifampin's label (effective February 11, 2026) does not name drospirenone/ethinyl estradiol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Drospirenone/ethinyl estradiol | Rifampin | |
|---|---|---|
| Labeled for | Acne, Birth control | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.151 per tablet 3-0.03 mg tablet | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once