What the FDA labels say about taking them together
Drospirenone/ethinyl estradiol and midazolam
Drospirenone/ethinyl estradiol's FDA label of May 29, 2025 names midazolam in its drug interactions section; the midazolam labels PlainMeds reads (4) do not name drospirenone/ethinyl estradiol. The drospirenone/ethinyl estradiol label: “… only to a weak increase in plasma concentrations of CYP3A4 substrates (e.g., midazolam) while plasma concentrations of CYP2C19 substrates and CYP1A2 substrates can have a weak or moderate increase.”
Check it at the source: the drospirenone/ethinyl estradiol FDA label on DailyMed (effective May 29, 2025, Bayer HealthCare Pharmaceuticals Inc.); the midazolam FDA label on DailyMed (effective January 1, 2024, Fresenius Kabi USA, LLC).
What does the drospirenone/ethinyl estradiol label say about midazolam?
Drospirenone/ethinyl estradiol label, drug interactionsCOCs Increasing the Plasma Concentrations of CYP450 Enzymes: In clinical studies, administration of a hormonal contraceptive containing EE did not lead to any increase or only to a weak increase in plasma concentrations of CYP3A4 substrates (e.g., midazolam) while plasma concentrations of CYP2C19 substrates (e.g., omeprazole and voriconazole) and CYP1A2 substrates (e.g., theophylline and tizanidine) can have a weak or moderate increase.
Source: FDA drug label (Yaz), Bayer HealthCare Pharmaceuticals Inc., effective May 29, 2025 (SPL set 065f33e4-b587-4e66-b896-ca9ab7b7c876), via openFDA; the full label on DailyMed
What does the midazolam label say about drospirenone/ethinyl estradiol?
Midazolam's label (effective January 1, 2024) and its 3 other brand-application labels do not name drospirenone/ethinyl estradiol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Midazolam), Fresenius Kabi USA, LLC, effective January 1, 2024 (SPL set 1cc9ba6e-fa1b-405e-9de8-720c567b2a73), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Drospirenone/ethinyl estradiol | Midazolam | |
|---|---|---|
| Labeled for | Acne, Birth control | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.151 per tablet 3-0.03 mg tablet | $0.233 per mL 2 mg/2 mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once