What the FDA labels say about taking them together
Drospirenone/ethinyl estradiol and levonorgestrel
Drospirenone/ethinyl estradiol's FDA label of May 29, 2025 names levonorgestrel in its warnings and precautions section; the levonorgestrel labels PlainMeds reads (4) do not name drospirenone/ethinyl estradiol. The drospirenone/ethinyl estradiol label: “… associated with a higher risk of venous thromboembolism (VTE) than COCs containing levonorgestrel or some other progestins.”
Check it at the source: the drospirenone/ethinyl estradiol FDA label on DailyMed (effective May 29, 2025, Bayer HealthCare Pharmaceuticals Inc.); the levonorgestrel FDA label on DailyMed (effective January 31, 2023, Foundation Consumer Healthcare LLC).
What does the drospirenone/ethinyl estradiol label say about levonorgestrel?
Drospirenone/ethinyl estradiol label, warnings and precautionsStart no earlier than 4 weeks after delivery, in women who are not breastfeeding. (5.1) COCs containing DRSP may be associated with a higher risk of venous thromboembolism (VTE) than COCs containing levonorgestrel or some other progestins.
Yasmin label (Bayer HealthCare Pharmaceuticals Inc., May 19, 2023), warnings and precautionsCOCs containing DRSP may be associated with a higher risk of venous thromboembolism (VTE) than COCs containing levonorgestrel or some other progestins.
Source: FDA drug label (Yasmin, NDA021098), Bayer HealthCare Pharmaceuticals Inc., effective May 19, 2023 (SPL set d7ea6a60-5a56-4f81-b206-9b27b7e58875), via openFDA
Source: FDA drug label (Yaz), Bayer HealthCare Pharmaceuticals Inc., effective May 29, 2025 (SPL set 065f33e4-b587-4e66-b896-ca9ab7b7c876), via openFDA; the full label on DailyMed
What does the levonorgestrel label say about drospirenone/ethinyl estradiol?
Levonorgestrel's label (effective January 31, 2023) and its 3 other brand-application labels do not name drospirenone/ethinyl estradiol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Plan B One-Step), Foundation Consumer Healthcare LLC, effective January 31, 2023 (SPL set 6ce6b40e-14ac-47bd-a648-ddf9e452e559), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Drospirenone/ethinyl estradiol | Levonorgestrel | |
|---|---|---|
| Labeled for | Acne, Birth control | Birth control |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.151 per tablet 3-0.03 mg tablet | $6.33 per tablet 1.5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once