What the FDA labels say about taking them together
Acetaminophen and drospirenone/ethinyl estradiol
Drospirenone/ethinyl estradiol's FDA label of May 29, 2025 names acetaminophen in its drug interactions section; the acetaminophen labels PlainMeds reads (4) do not name drospirenone/ethinyl estradiol. The drospirenone/ethinyl estradiol label: “Ascorbic acid and acetaminophen may increase plasma EE concentrations, possibly by inhibition of conjugation.”
Check it at the source: the acetaminophen FDA label on DailyMed (effective November 13, 2024, Kenvue Brands LLC); the drospirenone/ethinyl estradiol FDA label on DailyMed (effective May 29, 2025, Bayer HealthCare Pharmaceuticals Inc.).
What does the acetaminophen label say about drospirenone/ethinyl estradiol?
Acetaminophen's label (effective November 13, 2024) and its 3 other brand-application labels do not name drospirenone/ethinyl estradiol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tylenol 8 HR Arthritis Pain), Kenvue Brands LLC, effective November 13, 2024 (SPL set 3af22fc8-e4e0-4863-8696-6bc1257047cb), via openFDA; the full label on DailyMed
What does the drospirenone/ethinyl estradiol label say about acetaminophen?
Drospirenone/ethinyl estradiol label, drug interactionsAscorbic acid and acetaminophen may increase plasma EE concentrations, possibly by inhibition of conjugation.
Source: FDA drug label (Yaz), Bayer HealthCare Pharmaceuticals Inc., effective May 29, 2025 (SPL set 065f33e4-b587-4e66-b896-ca9ab7b7c876), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetaminophen | Drospirenone/ethinyl estradiol | |
|---|---|---|
| Labeled for | Fever, Cough and cold, Pain | Acne, Birth control |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0339 per unit 500 mg caplet | $0.151 per tablet 3-0.03 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once