What the FDA labels say about taking them together
Drospirenone/estetrol and nicotine
Drospirenone/estetrol's FDA label of May 11, 2023 names nicotine in its warnings and precautions section; the nicotine labels PlainMeds reads (2) do not name drospirenone/estetrol. The drospirenone/estetrol label: “In addition to cigarettes, use of other nicotine-containing products – including cigars, smokeless tobacco, hookah tobacco, e-cigarettes, and nicotine replacement therapy – may also increase the risk of serious …”
Check it at the source: the drospirenone/estetrol FDA label on DailyMed (effective May 11, 2023); the nicotine FDA label on DailyMed (effective July 25, 2024, Dr. Reddys Laboratories Inc.).
What does the drospirenone/estetrol label say about nicotine?
Drospirenone/estetrol label, warnings and precautionsIn addition to cigarettes, use of other nicotine-containing products – including cigars, smokeless tobacco, hookah tobacco, e-cigarettes, and nicotine replacement therapy – may also increase the risk of serious cardiovascular events from CHC use.
Source: FDA drug label (Nextstellis), Mayne Pharma, effective May 11, 2023 (SPL set c5270073-d083-4109-ae4b-156986175e0a), via openFDA; the full label on DailyMed
What does the nicotine label say about drospirenone/estetrol?
Nicotine's label (effective July 25, 2024) and its 1 other brand-application label do not name drospirenone/estetrol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nicotine transdermal system), Dr. Reddys Laboratories Inc., effective July 25, 2024 (SPL set e2391b29-9bac-fc09-f2a5-a3370bc4e2c3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Drospirenone/estetrol | Nicotine | |
|---|---|---|
| Labeled for | Birth control | Quitting smoking |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $7.67 per tablet 3-14.2 mg tablet | $1.87 per patch 21 mg/24hr patch |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once