What the FDA labels say about taking them together
Drospirenone/estetrol and lamotrigine
Drospirenone/estetrol's FDA label of May 11, 2023 names lamotrigine in its drug interactions section; the lamotrigine labels PlainMeds reads (3) do not name drospirenone/estetrol. The drospirenone/estetrol label: “Lamotrigine Clinical Effect Concomitant use of NEXTSTELLIS may decrease lamotrigine exposure, which may reduce efficacy of lamotrigine.”
Check it at the source: the drospirenone/estetrol FDA label on DailyMed (effective May 11, 2023); the lamotrigine FDA label on DailyMed (effective October 10, 2025).
What does the drospirenone/estetrol label say about lamotrigine?
Drospirenone/estetrol label, drug interactionsLamotrigine Clinical Effect Concomitant use of NEXTSTELLIS may decrease lamotrigine exposure [see Clinical Pharmacology (12.3) ], which may reduce efficacy of lamotrigine.
Source: FDA drug label (Nextstellis), Mayne Pharma, effective May 11, 2023 (SPL set c5270073-d083-4109-ae4b-156986175e0a), via openFDA; the full label on DailyMed
What does the lamotrigine label say about drospirenone/estetrol?
Lamotrigine's label (effective October 10, 2025) and its 2 other brand-application labels do not name drospirenone/estetrol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LAMICTAL), GlaxoSmithKline LLC, effective October 10, 2025 (SPL set d7e3572d-56fe-4727-2bb4-013ccca22678), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Drospirenone/estetrol | Lamotrigine | |
|---|---|---|
| Labeled for | Birth control | Seizures and epilepsy, Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $7.67 per tablet 3-14.2 mg tablet | $0.0268 per tablet 25 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once