What the FDA labels say about taking them together
Drospirenone and spironolactone
Drospirenone's FDA label of August 27, 2026 names spironolactone in its warnings and precautions section; the spironolactone labels PlainMeds reads (2) do not name drospirenone. The drospirenone label: “Hyperkalemia SLYND contains drospirenone, a progestin, which has anti-mineralocorticoid activity, including the potential for hyperkalemia in high-risk females, comparable to a 25 mg dose of spironolactone.”
Check it at the source: the drospirenone FDA label on DailyMed (effective August 27, 2026, Exeltis USA, Inc.); the spironolactone FDA label on DailyMed (effective November 28, 2025, Pfizer Laboratories Div Pfizer Inc).
What does the drospirenone label say about spironolactone?
Drospirenone label, warnings and precautionsHyperkalemia SLYND contains drospirenone, a progestin, which has anti-mineralocorticoid activity, including the potential for hyperkalemia in high-risk females, comparable to a 25 mg dose of spironolactone.
Source: FDA drug label (SLYND), Exeltis USA, Inc., effective August 27, 2026 (SPL set db32bc55-f295-4d87-9dbb-0a2f45573dcf), via openFDA; the full label on DailyMed
What does the spironolactone label say about drospirenone?
Spironolactone's label (effective November 28, 2025) and its 1 other brand-application label do not name drospirenone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Aldactone), Pfizer Laboratories Div Pfizer Inc, effective November 28, 2025 (SPL set 0fed2822-3a03-4b64-9857-c682fcd462bc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Drospirenone | Spironolactone | |
|---|---|---|
| Labeled for | Birth control | Heart failure, Edema (fluid retention), High blood pressure |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $6.61 per tablet 4 mg tablet | $0.0426 per tablet 25 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once