What the FDA labels say about taking them together
Drospirenone and rufinamide
Drospirenone's FDA label of August 27, 2026 names rufinamide in its drug interactions section; the rufinamide label PlainMeds reads does not name drospirenone. The drospirenone label: “… bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, rifabutin, rufinamide, aprepitant, and products containing St. John's wort.”
Check it at the source: the drospirenone FDA label on DailyMed (effective August 27, 2026, Exeltis USA, Inc.); the rufinamide FDA label on DailyMed (effective December 15, 2022, Eisai Inc.).
What does the drospirenone label say about rufinamide?
Drospirenone label, drug interactionsSome drugs or herbal products that may decrease the effectiveness of HCs include efavirenz, phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, rifabutin, rufinamide, aprepitant, and products containing St. John's wort.
Source: FDA drug label (SLYND), Exeltis USA, Inc., effective August 27, 2026 (SPL set db32bc55-f295-4d87-9dbb-0a2f45573dcf), via openFDA; the full label on DailyMed
What does the rufinamide label say about drospirenone?
Rufinamide's label (effective December 15, 2022) does not name drospirenone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Banzel), Eisai Inc., effective December 15, 2022 (SPL set 0a3fa925-1abd-458a-bd57-4ae780a1ef2d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Drospirenone | Rufinamide | |
|---|---|---|
| Labeled for | Birth control | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $6.61 per tablet 4 mg tablet | $0.203 per mL 40 mg/mL suspension |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once