What the FDA labels say about taking them together
Drospirenone and oxcarbazepine
Drospirenone's FDA label of August 27, 2026 names oxcarbazepine in its drug interactions section; the oxcarbazepine labels PlainMeds reads (2) do not name drospirenone. The drospirenone label: “Some drugs or herbal products that may decrease the effectiveness of HCs include efavirenz, phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, rifabutin, rufinamide …”
Check it at the source: the drospirenone FDA label on DailyMed (effective August 27, 2026, Exeltis USA, Inc.); the oxcarbazepine FDA label on DailyMed (effective December 16, 2025, Novartis Pharmaceuticals Corporation).
What does the drospirenone label say about oxcarbazepine?
Drospirenone label, drug interactionsSome drugs or herbal products that may decrease the effectiveness of HCs include efavirenz, phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, rifabutin, rufinamide, aprepitant, and products containing St. John's wort.
Source: FDA drug label (SLYND), Exeltis USA, Inc., effective August 27, 2026 (SPL set db32bc55-f295-4d87-9dbb-0a2f45573dcf), via openFDA; the full label on DailyMed
What does the oxcarbazepine label say about drospirenone?
Oxcarbazepine's label (effective December 16, 2025) and its 1 other brand-application label do not name drospirenone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Trileptal), Novartis Pharmaceuticals Corporation, effective December 16, 2025 (SPL set 4c5c86c8-ab7f-4fcf-bc1b-5a0b1fd0691b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Drospirenone | Oxcarbazepine | |
|---|---|---|
| Labeled for | Birth control | Seizures and epilepsy |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $6.61 per tablet 4 mg tablet | $0.167 per tablet 300 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once