What the FDA labels say about taking them together
Drospirenone and heparin
Drospirenone's FDA label of August 27, 2026 names heparin in its drug interactions section; the heparin labels PlainMeds reads (4) do not name drospirenone. The drospirenone label: “… receptor antagonists, potassium-sparing diuretics, potassium supplementation, heparin, aldosterone antagonists, and NSAIDS.”
Check it at the source: the drospirenone FDA label on DailyMed (effective August 27, 2026, Exeltis USA, Inc.); the heparin FDA label on DailyMed (effective November 28, 2025, Fresenius Kabi USA, LLC).
What does the drospirenone label say about heparin?
Drospirenone label, drug interactionsPotential to increase serum potassium concentration: There is a potential for an increase in serum potassium concentration in females taking SLYND with other drugs that may increase serum potassium concentration (for example, ACE inhibitors, angiotensin-II receptor antagonists, potassium-sparing diuretics, potassium supplementation, heparin, aldosterone antagonists, and NSAIDS [see Warnings and Precautions (5.1) ].
Source: FDA drug label (SLYND), Exeltis USA, Inc., effective August 27, 2026 (SPL set db32bc55-f295-4d87-9dbb-0a2f45573dcf), via openFDA; the full label on DailyMed
What does the heparin label say about drospirenone?
Heparin's label (effective November 28, 2025) and its 3 other brand-application labels do not name drospirenone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Heparin Sodium), Fresenius Kabi USA, LLC, effective November 28, 2025 (SPL set d55b4a63-0c04-4874-b74f-9e9b9e8b008c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Drospirenone | Heparin | |
|---|---|---|
| Labeled for | Birth control | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $6.61 per tablet 4 mg tablet | $1.18 per mL 5,000 unit/mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once