What the FDA labels say about taking them together
Drospirenone and estradiol
Drospirenone's FDA label of August 27, 2026 names estradiol in its warnings and precautions section; the estradiol labels PlainMeds reads (4) do not name drospirenone. The drospirenone label: “Treatment with SLYND leads to decreased estradiol serum levels.”
Check it at the source: the drospirenone FDA label on DailyMed (effective August 27, 2026, Exeltis USA, Inc.); the estradiol FDA label on DailyMed (effective April 3, 2024, Amneal Pharmaceuticals LLC).
What does the drospirenone label say about estradiol?
Drospirenone label, warnings and precautionsTreatment with SLYND leads to decreased estradiol serum levels.
Source: FDA drug label (SLYND), Exeltis USA, Inc., effective August 27, 2026 (SPL set db32bc55-f295-4d87-9dbb-0a2f45573dcf), via openFDA; the full label on DailyMed
What does the estradiol label say about drospirenone?
Estradiol's label (effective April 3, 2024) and its 3 other brand-application labels do not name drospirenone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (YUVAFEM), Amneal Pharmaceuticals LLC, effective April 3, 2024 (SPL set 30c7f6ba-7a9e-4853-b3e4-e00a46560224), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Drospirenone | Estradiol | |
|---|---|---|
| Labeled for | Birth control | Menopause symptoms, Breast cancer, Osteoporosis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $6.61 per tablet 4 mg tablet | $0.0635 per tablet 1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once