What the FDA labels say about taking them together
Dronedarone and erythromycin
Dronedarone's FDA label of May 29, 2025 names erythromycin in its contraindications section; the erythromycin labels PlainMeds reads (4) do not name dronedarone. The dronedarone label: “… telithromycin, clarithromycin, nefazodone, and ritonavir Concomitant use of erythromycin Concomitant use of drugs or herbal products that prolong the QT interval and might increase the risk of torsade de pointes, such …”
Check it at the source: the dronedarone FDA label on DailyMed (effective May 29, 2025, Sanofi-Aventis U.S. LLC); the erythromycin FDA label on DailyMed (effective August 1, 2024, Teva Pharmaceuticals USA, Inc.).
What does the dronedarone label say about erythromycin?
Dronedarone label, contraindications… Bradycardia <50 bpm Concomitant use of strong CYP3A inhibitors, such as ketoconazole, itraconazole, voriconazole, cyclosporine, telithromycin, clarithromycin, nefazodone, and ritonavir [see Drug Interactions (7.2) ] Concomitant use of erythromycin [see Clinical Pharmacology (12.3) ] Concomitant use of drugs or herbal products that prolong the QT interval and might increase the risk of torsade de pointes, such as phenothiazine antipsychotics, tricyclic antidepressants, certain oral macrolide antibiotics, and Class I and III antiarrhythmics Liver or lung toxicity related to the previous use of amiodarone QTc interval >500 ms or PR interval >280 ms Severe hepatic impairment Hypersensitivity to …
Source: FDA drug label (Multaq), Sanofi-Aventis U.S. LLC, effective May 29, 2025 (SPL set 7fa41601-7fb5-4155-8e50-2ae903f0d2d6), via openFDA; the full label on DailyMed
What does the erythromycin label say about dronedarone?
Erythromycin's label (effective August 1, 2024) and its 3 other brand-application labels do not name dronedarone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Erythromycin), Teva Pharmaceuticals USA, Inc., effective August 1, 2024 (SPL set 75a0bd5a-d09f-483b-bfd8-f8343b149eb2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dronedarone | Erythromycin | |
|---|---|---|
| Labeled for | n/a | Bacterial infections, Acne |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $13.19 per tablet 400 mg tablet | $1.96 per tablet 250 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once