What the FDA labels say about taking them together
Doxorubicin and vincristine
Doxorubicin's FDA label of May 5, 2026 names vincristine in its drug interactions section; the vincristine label PlainMeds reads does not name doxorubicin. The doxorubicin label: “In 11 patients with refractory leukemia treated with 6-mercaptopurine and doxorubicin hydrochloride alone or with vincristine and prednisone, all developed hepatic dysfunction manifested by increased total serum …”
Check it at the source: the doxorubicin FDA label on DailyMed (effective May 5, 2026, Pfizer Laboratories Div Pfizer Inc); the vincristine FDA label on DailyMed (effective February 17, 2026, Hospira, Inc.).
What does the doxorubicin label say about vincristine?
Doxorubicin label, drug interactionsIn 11 patients with refractory leukemia treated with 6-mercaptopurine (500 mg/m 2 intravenously daily for 5 days per cycle every 2–3 weeks) and doxorubicin hydrochloride (50 mg/m 2 intravenous once per cycle every 2–3 weeks) alone or with vincristine and prednisone, all developed hepatic dysfunction manifested by increased total serum bilirubin, alkaline phosphatase and aspartate aminotransferase.
Source: FDA drug label (Doxorubicin Hydrochloride), Pfizer Laboratories Div Pfizer Inc, effective May 5, 2026 (SPL set 1fd148fb-0fbc-4b6f-b790-23546fb46a71), via openFDA; the full label on DailyMed
What does the vincristine label say about doxorubicin?
Vincristine's label (effective February 17, 2026) does not name doxorubicin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (VinCRIStine Sulfate), Hospira, Inc., effective February 17, 2026 (SPL set b22e4c8e-dbe1-4d4b-a026-e1812974071c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Doxorubicin | Vincristine | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma, Breast cancer | Leukemia, lymphoma and myeloma |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once