What the FDA labels say about taking them together
Doxorubicin and pertuzumab
Pertuzumab's FDA label of April 30, 2026 names doxorubicin in its warnings and precautions section; the doxorubicin labels PlainMeds reads (2) do not name pertuzumab. The pertuzumab label: “… treatment or a cumulative prior anthracycline exposure to > 360 mg/m 2 of doxorubicin or its equivalent.”
Check it at the source: the doxorubicin FDA label on DailyMed (effective May 5, 2026, Pfizer Laboratories Div Pfizer Inc); the pertuzumab FDA label on DailyMed (effective April 30, 2026, Genentech, Inc.).
What does the doxorubicin label say about pertuzumab?
Doxorubicin's label (effective May 5, 2026) and its 1 other brand-application label do not name pertuzumab in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Doxorubicin Hydrochloride), Pfizer Laboratories Div Pfizer Inc, effective May 5, 2026 (SPL set 1fd148fb-0fbc-4b6f-b790-23546fb46a71), via openFDA; the full label on DailyMed
What does the pertuzumab label say about doxorubicin?
Pertuzumab label, warnings and precautionsPERJETA has not been studied in patients with a pretreatment LVEF value of < 50%, a prior history of CHF, decreases in LVEF to < 50% during prior trastuzumab therapy, or conditions that could impair left ventricular function such as uncontrolled hypertension, recent myocardial infarction, serious cardiac arrhythmia requiring treatment or a cumulative prior anthracycline exposure to > 360 mg/m 2 of doxorubicin or its equivalent.
Source: FDA drug label (PERJETA), Genentech, Inc., effective April 30, 2026 (SPL set 17f85d17-ab71-4f5b-9fe3-0b8c822f69ff), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Doxorubicin | Pertuzumab | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma, Breast cancer | Breast cancer |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once