What the FDA labels say about taking them together
Doxepin and paroxetine
Doxepin's FDA label (Prudoxin) of June 29, 2017 names paroxetine in its drug interactions section; paroxetine's label does not name doxepin itself but warns about its class (Tricyclic antidepressants). The doxepin label: “While all the selective serotonin reuptake inhibitors (SSRIs), e.g., fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition.”
Check it at the source: the doxepin FDA label on DailyMed (effective December 30, 2025, Leading Pharma, LLC); the paroxetine FDA label on DailyMed (effective February 12, 2026, Mylan Pharmaceuticals Inc.).
What does the doxepin label say about paroxetine?
Prudoxin label (Mylan Pharmaceuticals Inc., June 29, 2017), drug interactionsWhile all the selective serotonin reuptake inhibitors (SSRIs), e.g., fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition.
Source: FDA drug label (Prudoxin, NDA020126), Mylan Pharmaceuticals Inc., effective June 29, 2017 (SPL set ca53346b-8ab3-4722-98f6-cf272706d3fa), via openFDA
Source: FDA drug label (DOXEPIN HYDROCHLORIDE), Leading Pharma, LLC, effective December 30, 2025 (SPL set e6a4cb10-1928-4abe-8797-404c9ddc37dd), via openFDA; the full label on DailyMed
What does the paroxetine label say about doxepin?
Paroxetine's label does not name doxepin itself; it warns about its class (Tricyclic antidepressants):
Paroxetine label, drug interactionsIf serotonin syndrome occurs, consider discontinuation of paroxetine tablets and/or concomitant serotonergic drugs [see Warnings and Precautions (5.2) ]. Examples other SSRIs, SNRIs, triptans, tricyclic antidepressants, opioids, lithium, tryptophan, buspirone, amphetamines, and St. John’s Wort.
Paroxetine label, warnings and precautionsThe risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines and St. John’s Wort) and with drugs that impair metabolism of serotonin, i.e., MAOIs [see Contraindications (4), Drug Interactions (7.1) ].
Source: FDA drug label (Paroxetine), Mylan Pharmaceuticals Inc., effective February 12, 2026 (SPL set 89dd7e24-85fc-4152-89ea-47ec2b48a1ed), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Doxepin | Paroxetine | |
|---|---|---|
| Labeled for | Depression, Anxiety, Eczema (atopic dermatitis), Insomnia | Depression, Anxiety, Menopause symptoms |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0779 per capsule 10 mg capsule | $0.0611 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once