What the FDA labels say about taking them together
Doxepin and flecainide
Doxepin's FDA label (Prudoxin) of June 29, 2017 names flecainide in its drug interactions section; the flecainide label PlainMeds reads does not name doxepin.
Check it at the source: the doxepin FDA label on DailyMed (effective December 30, 2025, Leading Pharma, LLC); the flecainide FDA label on DailyMed (effective June 11, 2026, Amneal Pharmaceuticals of New York LLC).
What does the doxepin label say about flecainide?
Prudoxin label (Mylan Pharmaceuticals Inc., June 29, 2017), drug interactionsThe drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide).
Source: FDA drug label (Prudoxin, NDA020126), Mylan Pharmaceuticals Inc., effective June 29, 2017 (SPL set ca53346b-8ab3-4722-98f6-cf272706d3fa), via openFDA
Source: FDA drug label (DOXEPIN HYDROCHLORIDE), Leading Pharma, LLC, effective December 30, 2025 (SPL set e6a4cb10-1928-4abe-8797-404c9ddc37dd), via openFDA; the full label on DailyMed
What does the flecainide label say about doxepin?
Flecainide's label (effective June 11, 2026) does not name doxepin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Flecainide Acetate), Amneal Pharmaceuticals of New York LLC, effective June 11, 2026 (SPL set ee9595d5-08a1-4529-9215-ddc3c7f929c4), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Doxepin | Flecainide | |
|---|---|---|
| Labeled for | Depression, Anxiety, Eczema (atopic dermatitis), Insomnia | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0779 per capsule 10 mg capsule | $0.171 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once