What the FDA labels say about taking them together
Doxapram and epinephrine
Epinephrine's FDA label of July 13, 2026 names doxapram in its drug interactions section; the doxapram label PlainMeds reads does not name epinephrine. The epinephrine label: “… blockers, tricyclic antidepressants, MAO inhibitors, COMT inhibitors, clonidine, doxapram, oxytocin, levothyroxine sodium, and certain antihistamines. …”
Check it at the source: the doxapram FDA label on DailyMed (effective April 9, 2024, Hikma Pharmaceuticals USA Inc.); the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions).
What does the doxapram label say about epinephrine?
Doxapram's label (effective April 9, 2024) does not name epinephrine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Dopram), Hikma Pharmaceuticals USA Inc., effective April 9, 2024 (SPL set b8eb330a-a75b-46cb-b694-5be9327ed2eb), via openFDA; the full label on DailyMed
What does the epinephrine label say about doxapram?
Epinephrine label, drug interactionsDRUG INTERACTIONS Drugs that counter the pressor effects of epinephrine include alpha blockers, vasodilators such as nitrates, diuretics, antihypertensives, and ergot alkaloids. ( 7 .1) Drugs that potentiate the effects of epinephrine include sympathomimetics, beta blockers, tricyclic antidepressants, MAO inhibitors, COMT inhibitors, clonidine, doxapram, oxytocin, levothyroxine sodium, and certain antihistamines. ( 7 .2) Drugs that increase the arrhythmogenic potential of epinephrine include beta blockers, cyclopropane and halogenated hydrocarbon anesthetics, quinidine, antihistamines, exogenous thyroid hormones, diuretics, and cardiac glycosides.
Epinephrine label (BPI Labs, LLC, December 26, 2025), drug interactionsDRUG INTERACTIONS Drugs antagonizing pressor effects of epinephrine α-blockers, such as phentolamine Vasodilators, such as nitrates Diuretics Antihypertensives Ergot alkaloids Drugs potentiating pressor effects of epinephrine Sympathomimetics β-blockers, such as propranolol Tricyclic anti-depressants Monoamine oxidase (MAO) inhibitors Catechol-O-methyl transferase (COMT) inhibitors, such as entacapone Clonidine Doxapram Oxytocin Drugs potentiating arrhythmogenic effects of epinephrine Patients who are concomitantly receiving any of the following drugs should be observed carefully for the development of cardiac arrhythmias [see Warnings and Precautions (5.6) and Adverse Reactions (6) ]. …
Source: FDA drug label (Epinephrine, NDA205029), BPI Labs, LLC, effective December 26, 2025 (SPL set db18519b-82a9-435b-85c7-a040d644f057), via openFDA
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Doxapram | Epinephrine | |
|---|---|---|
| Labeled for | n/a | Asthma |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $123.51 per unit 0.15 mg auto-injct |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once