What the FDA labels say about taking them together
Doravirine/islatravir and pentostatin
Doravirine/islatravir's FDA label of April 20, 2026 names pentostatin in its drug interactions section; the pentostatin label PlainMeds reads does not name doravirine/islatravir. The doravirine/islatravir label: “Co-administration with pentostatin is not recommended as it may cause an increase in plasma concentrations of islatravir.”
Check it at the source: the doravirine/islatravir FDA label on DailyMed (effective April 20, 2026, Merck Sharp & Dohme LLC); the pentostatin FDA label on DailyMed (effective July 1, 2026, Hospira, Inc.).
What does the doravirine/islatravir label say about pentostatin?
Doravirine/islatravir label, drug interactionsConcomitant Drug Class/Drug Name: pentostatin; Effect on Concentration: ↑ islatravir; Clinical Comment: Co-administration with pentostatin is not recommended as it may cause an increase in plasma concentrations of islatravir.
Source: FDA drug label (IDVYNSO), NDA216964 (Msd), as published by Merck Sharp & Dohme LLC, effective April 20, 2026 (SPL set 11aaeb53-9848-433c-be7f-db8a5bc0b26f), via openFDA; the full label on DailyMed
What does the pentostatin label say about doravirine/islatravir?
Pentostatin's label (effective July 1, 2026) does not name doravirine/islatravir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nipent), Hospira, Inc., effective July 1, 2026 (SPL set 674e0e6d-46ed-4868-9196-04019d667716), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Doravirine/islatravir | Pentostatin | |
|---|---|---|
| Labeled for | HIV | Leukemia, lymphoma and myeloma |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once