What the FDA labels say about taking them together
Doravirine and efavirenz
Doravirine's FDA label of July 8, 2026 names efavirenz in its drug interactions section; the efavirenz label PlainMeds reads does not name doravirine. The doravirine label: “Use with efavirenz, etravirine, or nevirapine is not recommended.”
Check it at the source: the doravirine FDA label on DailyMed (effective July 8, 2026, Merck Sharp & Dohme LLC); the efavirenz FDA label on DailyMed (effective March 31, 2024, Cipla USA Inc.).
What does the doravirine label say about efavirenz?
Doravirine label, drug interactionsConcomitant Drug Class/Drug Name: efavirenz etravirine nevirapine; Effect on Concentration: ↓ doravirine; Clinical Comment: Use with efavirenz, etravirine, or nevirapine is not recommended.
Source: FDA drug label (PIFELTRO), Merck Sharp & Dohme LLC, effective July 8, 2026 (SPL set 76ce1f00-28c0-4314-bd2c-d473fe3d0970), via openFDA; the full label on DailyMed
What does the efavirenz label say about doravirine?
Efavirenz's label (effective March 31, 2024) does not name doravirine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Efavirenz), Cipla USA Inc., effective March 31, 2024 (SPL set 92603fa5-7a2c-4bfb-9a70-aadb4fba952c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Doravirine | Efavirenz | |
|---|---|---|
| Labeled for | HIV | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $60.79 per tablet 100 mg tablet | $1.28 per tablet 600 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once