Dopamine and Imipramine Interaction
Drug interaction information between Dopamine and Imipramine.
Dopamine and Imipramine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dopamine and Imipramine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This antidepressant can make your body more sensitive to dopamine, which may cause a bigger increase in blood pressure than expected. It stops the body from clearing dopamine as quickly as it should.
FDA Label Information
Examples: amitriptyline, desipramine, doxepin, imipramine, nortriptyline.
Dopamine Also Interacts With
- Carbidopa/Levodopa moderate
- Deutetrabenazine moderate
- Digoxin moderate
- Tetrabenazine moderate
- Tranylcypromine moderate
Imipramine Also Interacts With
- Epinephrine moderate
- Norepinephrine moderate
- Zolpidem moderate
- Sertraline minor
- Paroxetine minor
Frequently Asked Questions
What SPL severity band is on file for Dopamine + Imipramine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dopamine has 28 labeled pairs on file vs Imipramine's 20. In the minor band specifically: Dopamine has 23 (also Amitriptyline, Doxepin, Linezolid, Nortriptyline); Imipramine has 17 (also Sertraline, Paroxetine, Flecainide, Propafenone).
What mechanism field is on file for Dopamine and Imipramine?
This antidepressant can make your body more sensitive to dopamine, which may cause a bigger increase in blood pressure than expected. It stops the body from clearing dopamine as quickly as it should.
Dopamine's labeled portfolio outnumbers Imipramine
SPL source-record counts only. This page's band is minor · classes on file: Dopamine (Inotropic / Vasopressor); Imipramine (Tricyclic Antidepressant (TCA)).
0 major · 5 moderate · 23 minor · 28 total
- Other minor peers for Dopamine
- Amitriptyline
- Doxepin
- Linezolid
- Nortriptyline
0 major · 3 moderate · 17 minor · 20 total
- Other minor peers for Imipramine
- Sertraline
- Paroxetine
- Flecainide
- Propafenone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.