What the FDA labels say about taking them together
Donepezil/memantine and ketoconazole
Donepezil/memantine's FDA label of December 17, 2024 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name donepezil/memantine.
Check it at the source: the donepezil/memantine FDA label on DailyMed (effective December 17, 2024, Amneal Pharmaceuticals NY LLC); the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC).
What does the donepezil/memantine label say about ketoconazole?
Donepezil/memantine label, drug interactionsDrugs on the Metabolism of Donepezil Inhibitors of CYP3A4 (e.g., ketoconazole) and CYP2D6 (e.g., quinidine), inhibit donepezil metabolism in vitro.
Source: FDA drug label (Memantine and Donepezil Hydrochlorides Extended-release), Amneal Pharmaceuticals NY LLC, effective December 17, 2024 (SPL set 2335950c-be3b-4248-ad04-e9763aee47d2), via openFDA; the full label on DailyMed
What does the ketoconazole label say about donepezil/memantine?
Ketoconazole's label (effective January 28, 2026) does not name donepezil/memantine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Donepezil/memantine | Ketoconazole | |
|---|---|---|
| Labeled for | Alzheimer's disease | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $8.44 per unit 28-10 mg | $0.249 per gram 2% cream |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once