What the FDA labels say about taking them together
Dolutegravir and sucralfate
Dolutegravir's FDA label of May 22, 2026 names sucralfate in its drug interactions section; the sucralfate labels PlainMeds reads (2) do not name dolutegravir.
Check it at the source: the dolutegravir FDA label on DailyMed (effective May 22, 2026, ST. MARY'S MEDICAL PARK PHARMACY); the sucralfate FDA label on DailyMed (effective September 2, 2026, Preferred Pharmaceuticals Inc.).
What does the dolutegravir label say about sucralfate?
Dolutegravir label, drug interactionsConcomitant Drug Class/Drug Name: Medications containing polyvalent cations (e.g., Mg or Al): Cation-containing antacids a or laxatives Sucralfate Buffered medications; Effect on Concentration of Dolutegravir and/or Concomitant Drug: ↓Dolutegravir; Clinical Comment: Administer TIVICAY or TIVICAY PD 2 hours before or 6 hours after taking medications containing polyvalent cations.
Tivicay Pd label (ViiV Healthcare Company, August 25, 2026), drug interactionsTIVICAY or TIVICAY PD should be taken 2 hours before or 6 hours after taking cation-containing antacids or laxatives, sucralfate, oral supplements containing iron or calcium, or buffered medications.
Source: FDA drug label (Tivicay Pd, NDA213983), ViiV Healthcare Company, effective August 25, 2026 (SPL set 63df5af3-b8ac-4e76-9830-2dbb340af922), via openFDA
Source: FDA drug label (Tivicay), NDA204790 (Viiv Hlthcare), as published by ST. MARY'S MEDICAL PARK PHARMACY, effective May 22, 2026 (SPL set 485bc9db-8665-9f5a-e063-6394a90a7921), via openFDA; the full label on DailyMed
What does the sucralfate label say about dolutegravir?
Sucralfate's label (effective September 2, 2026) and its 1 other brand-application label do not name dolutegravir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Sucralfate), NDA018333 (Abbvie), as published by Preferred Pharmaceuticals Inc., effective September 2, 2026 (SPL set 536b8c00-13ab-4397-a754-63a1c92bf883), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dolutegravir | Sucralfate | |
|---|---|---|
| Labeled for | HIV | Acid reflux and ulcers |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $77.64 per tablet 50 mg tablet | $0.173 per tablet 1 g tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once