What the FDA labels say about taking them together
Dofetilide and tafenoquine
Tafenoquine's FDA label of January 10, 2025 names dofetilide in its drug interactions section; the dofetilide label PlainMeds reads does not name tafenoquine. The tafenoquine label: “Avoid coadministration of ARAKODA with OCT2 and MATE substrates.”
Check it at the source: the dofetilide FDA label on DailyMed (effective April 21, 2026, Pfizer Laboratories Div Pfizer Inc); the tafenoquine FDA label on DailyMed (effective January 10, 2025, 60 Degrees Pharmaceuticals, INC.).
What does the dofetilide label say about tafenoquine?
Dofetilide's label (effective April 21, 2026) does not name tafenoquine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tikosyn), Pfizer Laboratories Div Pfizer Inc, effective April 21, 2026 (SPL set 02438044-d6a3-49e9-a1ac-3aad21ef2c8c), via openFDA; the full label on DailyMed
What does the tafenoquine label say about dofetilide?
Tafenoquine label, drug interactionsAvoid coadministration of ARAKODA with OCT2 and MATE substrates (e.g., dofetilide, metformin).
Source: FDA drug label (Krintafel, NDA210795), GlaxoSmithKline LLC, effective August 2, 2023 (SPL set 5cf989d5-36f5-4561-a30b-9fcb9deb6b6a), via openFDA
Source: FDA drug label (Arakoda), 60 Degrees Pharmaceuticals, INC., effective January 10, 2025 (SPL set 299e49d8-470f-4779-a010-4a1ee0e0c6cd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dofetilide | Tafenoquine | |
|---|---|---|
| Labeled for | Atrial fibrillation | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.203 per capsule 125 mcg capsule | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once