What the FDA labels say about taking them together
Dofetilide and megestrol
Dofetilide's FDA label of April 21, 2026 names megestrol in its contraindications section; the megestrol label PlainMeds reads does not name dofetilide.
Check it at the source: the dofetilide FDA label on DailyMed (effective April 21, 2026, Pfizer Laboratories Div Pfizer Inc); the megestrol FDA label on DailyMed (effective April 22, 2022, Strides Pharma Science Limited).
What does the dofetilide label say about megestrol?
Dofetilide label, contraindicationsIn addition, other known inhibitors of the renal cation transport system such as prochlorperazine, dolutegravir and megestrol should not be used in patients on TIKOSYN.
Source: FDA drug label (Tikosyn), Pfizer Laboratories Div Pfizer Inc, effective April 21, 2026 (SPL set 02438044-d6a3-49e9-a1ac-3aad21ef2c8c), via openFDA; the full label on DailyMed
What does the megestrol label say about dofetilide?
Megestrol's label (effective April 22, 2022) does not name dofetilide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Megestrol Acetate), Strides Pharma Science Limited, effective April 22, 2022 (SPL set 9f7365a0-67cf-45fc-a914-e40a4507a063), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dofetilide | Megestrol | |
|---|---|---|
| Labeled for | Atrial fibrillation | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.203 per capsule 125 mcg capsule | $0.241 per tablet 40 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once