What the FDA labels say about taking them together
Docetaxel and ketoconazole
Docetaxel's FDA label of July 15, 2025 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name docetaxel. The docetaxel label: “In vivo studies showed that the exposure of docetaxel increased 2.2-fold when it was coadministered with ketoconazole, a potent inhibitor of CYP3A4.”
Check it at the source: the docetaxel FDA label on DailyMed (effective July 15, 2025, Avyxa Pharma, LLC); the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC).
What does the docetaxel label say about ketoconazole?
Docetaxel label, drug interactionsIn vivo studies showed that the exposure of docetaxel increased 2.2-fold when it was coadministered with ketoconazole, a potent inhibitor of CYP3A4.
Source: FDA drug label (DOCIVYX), Avyxa Pharma, LLC, effective July 15, 2025 (SPL set 4763744e-360e-4d37-be05-cce4114548cd), via openFDA; the full label on DailyMed
What does the ketoconazole label say about docetaxel?
Ketoconazole's label (effective January 28, 2026) does not name docetaxel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Docetaxel | Ketoconazole | |
|---|---|---|
| Labeled for | Breast cancer, Lung cancer, Prostate cancer | Fungal infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.249 per gram 2% cream |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once