What the FDA labels say about taking them together
Divalproex and sodium oxybate
Sodium oxybate's FDA label of July 1, 2025 names divalproex in its drug interactions section; the divalproex labels PlainMeds reads (3) do not name sodium oxybate. The sodium oxybate label: “Concomitant use with divalproex sodium: An initial reduction in Xyrem dose of at least 20% is recommended.”
Check it at the source: the divalproex FDA label on DailyMed (effective March 31, 2026, AbbVie Inc.); the sodium oxybate FDA label on DailyMed (effective July 1, 2025, Jazz Pharmaceuticals, Inc.).
What does the divalproex label say about sodium oxybate?
Divalproex's label (effective March 31, 2026) and its 2 other brand-application labels do not name sodium oxybate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Depakote), AbbVie Inc., effective March 31, 2026 (SPL set 08a65cf4-7749-4ceb-6895-8f4805e2b01f), via openFDA; the full label on DailyMed
What does the sodium oxybate label say about divalproex?
Sodium oxybate label, drug interactionsConcomitant use with divalproex sodium: An initial reduction in Xyrem dose of at least 20% is recommended ( 2.5 , 7.2 ).
Source: FDA drug label (Xyrem), Jazz Pharmaceuticals, Inc., effective July 1, 2025 (SPL set 926eb076-a4a8-45e4-91ef-411f0aa4f3ca), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Divalproex | Sodium oxybate | |
|---|---|---|
| Labeled for | Bipolar disorder, Migraine, Seizures and epilepsy | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.194 per tablet 500 mg tablet | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once