What the FDA labels say about taking them together
Divalproex and rifampin
Divalproex's FDA label of March 31, 2026 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name divalproex. The divalproex label: “DRUG INTERACTIONS Hepatic enzyme-inducing drugs can increase valproate clearance, while enzyme inhibitors (e.g., felbamate) can decrease valproate clearance.”
Check it at the source: the divalproex FDA label on DailyMed (effective March 31, 2026, AbbVie Inc.); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the divalproex label say about rifampin?
Divalproex label, drug interactionsDRUG INTERACTIONS Hepatic enzyme-inducing drugs (e.g., phenytoin, carbamazepine, phenobarbital, primidone, rifampin) can increase valproate clearance, while enzyme inhibitors (e.g., felbamate) can decrease valproate clearance.
Source: FDA drug label (Depakote), AbbVie Inc., effective March 31, 2026 (SPL set 08a65cf4-7749-4ceb-6895-8f4805e2b01f), via openFDA; the full label on DailyMed
What does the rifampin label say about divalproex?
Rifampin's label (effective February 11, 2026) does not name divalproex in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Divalproex | Rifampin | |
|---|---|---|
| Labeled for | Bipolar disorder, Migraine, Seizures and epilepsy | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.194 per tablet 500 mg tablet | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once