What the FDA labels say about taking them together
Divalproex and primidone
Divalproex's FDA label of March 31, 2026 names primidone in its drug interactions section; primidone's label does not name divalproex itself but warns about its class (Anti-seizure medicines). The divalproex label: “DRUG INTERACTIONS Hepatic enzyme-inducing drugs can increase valproate clearance, while enzyme inhibitors (e.g., felbamate) can decrease valproate clearance.”
Check it at the source: the divalproex FDA label on DailyMed (effective March 31, 2026, AbbVie Inc.); the primidone FDA label on DailyMed (effective September 10, 2026, Bausch Health US, LLC).
What does the divalproex label say about primidone?
Divalproex label, drug interactionsDRUG INTERACTIONS Hepatic enzyme-inducing drugs (e.g., phenytoin, carbamazepine, phenobarbital, primidone, rifampin) can increase valproate clearance, while enzyme inhibitors (e.g., felbamate) can decrease valproate clearance.
Source: FDA drug label (Depakote), AbbVie Inc., effective March 31, 2026 (SPL set 08a65cf4-7749-4ceb-6895-8f4805e2b01f), via openFDA; the full label on DailyMed
What does the primidone label say about divalproex?
Primidone's label does not name divalproex itself; it warns about its class (Anti-seizure medicines):
Primidone label, warningsSuicidal Behavior and Ideation Antiepileptic drugs (AEDs), including MYSOLINE, increase the risk of suicidal thoughts or behavior in patients taking these drugs for any indication.
Primidone label, warningsPatients treated with any AED for any indication should be monitored for the emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior.
Source: FDA drug label (Mysoline), NDA009170 (Valeant), as published by Bausch Health US, LLC, effective September 10, 2026 (SPL set af593171-dabb-4ea3-b44c-89ed457b2c46), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Divalproex | Primidone | |
|---|---|---|
| Labeled for | Bipolar disorder, Migraine, Seizures and epilepsy | Seizures and epilepsy |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.194 per tablet 500 mg tablet | $0.0914 per tablet 50 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once