What the FDA labels say about taking them together
Divalproex and paliperidone
Paliperidone's FDA label of January 31, 2025 names divalproex in its drug interactions section; the divalproex labels PlainMeds reads (3) do not name paliperidone. The paliperidone label: “Conversely, on discontinuation of the strong inducer, it may be necessary to decrease the dose of INVEGA. Co-administration of divalproex sodium increased C max and AUC of paliperidone by approximately 50%.”
Check it at the source: the divalproex FDA label on DailyMed (effective March 31, 2026, AbbVie Inc.); the paliperidone FDA label on DailyMed (effective January 31, 2025, Janssen Pharmaceuticals, Inc.).
What does the divalproex label say about paliperidone?
Divalproex's label (effective March 31, 2026) and its 2 other brand-application labels do not name paliperidone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Depakote), AbbVie Inc., effective March 31, 2026 (SPL set 08a65cf4-7749-4ceb-6895-8f4805e2b01f), via openFDA; the full label on DailyMed
What does the paliperidone label say about divalproex?
Paliperidone label, drug interactionsConversely, on discontinuation of the strong inducer, it may be necessary to decrease the dose of INVEGA. ( 7.2 ) Co-administration of divalproex sodium increased C max and AUC of paliperidone by approximately 50%.
Invega Sustenna label (Janssen Pharmaceuticals, Inc., February 14, 2025), drug interactionsInteractions with INVEGA SUSTENNA Clinically meaningful pharmacokinetic interaction between INVEGA SUSTENNA and valproate (including valproic acid and divalproex sodium) is not expected.
Source: FDA drug label (Invega Sustenna, NDA022264), Janssen Pharmaceuticals, Inc., effective February 14, 2025 (SPL set 1af14e42-951d-414d-8564-5d5fce138554), via openFDA
Source: FDA drug label (INVEGA), Janssen Pharmaceuticals, Inc., effective January 31, 2025 (SPL set 7b8e5b26-b9e4-4704-921b-3c3c0d159916), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Divalproex | Paliperidone | |
|---|---|---|
| Labeled for | Bipolar disorder, Migraine, Seizures and epilepsy | Schizophrenia |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.194 per tablet 500 mg tablet | $0.972 per tablet 3 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once