What the FDA labels say about taking them together
Divalproex and nortriptyline
Divalproex's FDA label of March 31, 2026 names nortriptyline in its drug interactions section; the nortriptyline label PlainMeds reads does not name divalproex. The divalproex label: “… and titrate to clinically effective dose Dosage adjustment of amitriptyline/nortriptyline, propofol, warfarin, and zidovudine may be necessary if used concomitantly with Depakote Topiramate:”
Check it at the source: the divalproex FDA label on DailyMed (effective March 31, 2026, AbbVie Inc.); the nortriptyline FDA label on DailyMed (effective December 4, 2024).
What does the divalproex label say about nortriptyline?
Divalproex label, drug interactionsMonitoring of valproate concentrations is recommended ( 7.1 ) Co-administration of valproate can affect the pharmacokinetics of other drugs (e.g., diazepam, ethosuximide, lamotrigine, phenytoin) by inhibiting their metabolism or protein binding displacement ( 7.2 ) Patients stabilized on rufinamide should begin valproate therapy at a low dose, and titrate to clinically effective dose ( 7.2 ) Dosage adjustment of amitriptyline/nortriptyline, propofol, warfarin, and zidovudine may be necessary if used concomitantly with Depakote ( 7.2 ) Topiramate:
Source: FDA drug label (Depakote), AbbVie Inc., effective March 31, 2026 (SPL set 08a65cf4-7749-4ceb-6895-8f4805e2b01f), via openFDA; the full label on DailyMed
What does the nortriptyline label say about divalproex?
Nortriptyline's label (effective December 4, 2024) does not name divalproex in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PAMELOR), SpecGx LLC, effective December 4, 2024 (SPL set e17dc299-f52d-414d-ab6e-e809bd6f8acb), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Divalproex | Nortriptyline | |
|---|---|---|
| Labeled for | Bipolar disorder, Migraine, Seizures and epilepsy | Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.194 per tablet 500 mg tablet | $0.113 per capsule 10 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once