What the FDA labels say about taking them together
Divalproex and glutamine
Divalproex's FDA label of March 31, 2026 names glutamine in its warnings and precautions section; the glutamine label PlainMeds reads does not name divalproex.
Check it at the source: the divalproex FDA label on DailyMed (effective March 31, 2026, AbbVie Inc.); the glutamine FDA label on DailyMed (effective June 20, 2025).
What does the divalproex label say about glutamine?
Divalproex label, warnings and precautions1) those with a history of unexplained encephalopathy or coma, encephalopathy associated with a protein load, pregnancy-related or postpartum encephalopathy, unexplained mental retardation, or history of elevated plasma ammonia or glutamine;
Source: FDA drug label (Depakote), AbbVie Inc., effective March 31, 2026 (SPL set 08a65cf4-7749-4ceb-6895-8f4805e2b01f), via openFDA; the full label on DailyMed
What does the glutamine label say about divalproex?
Glutamine's label (effective June 20, 2025) does not name divalproex in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Endari), Emmaus Medical, Inc., effective June 20, 2025 (SPL set d5a783f4-12ef-4326-8faa-40018e45ba3b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Divalproex | Glutamine | |
|---|---|---|
| Labeled for | Bipolar disorder, Migraine, Seizures and epilepsy | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.194 per tablet 500 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once