What the FDA labels say about taking them together
Disulfiram and fexinidazole
Fexinidazole's FDA label of May 2, 2025 names disulfiram in its warnings and precautions section; the disulfiram label PlainMeds reads does not name fexinidazole. The fexinidazole label: “Advise patients to avoid consumption of alcohol during treatment with and for at least 48 hours after completing therapy. Risk of Psychotic Reactions Due to Concomitant Use with Disulfiram:”
Check it at the source: the disulfiram FDA label on DailyMed (effective August 20, 2024, Sigmapharm Laboratories, LLC); the fexinidazole FDA label on DailyMed (effective May 2, 2025, Sanofi-Aventis U.S. LLC).
What does the disulfiram label say about fexinidazole?
Disulfiram's label (effective August 20, 2024) does not name fexinidazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Disulfiram), Sigmapharm Laboratories, LLC, effective August 20, 2024 (SPL set 40f5497f-fe84-43b2-8ff4-32d59edf3917), via openFDA; the full label on DailyMed
What does the fexinidazole label say about disulfiram?
Fexinidazole label, warnings and precautionsAdvise patients to avoid consumption of alcohol during treatment with and for at least 48 hours after completing therapy. ( 2.1 , 5.6 ) Risk of Psychotic Reactions Due to Concomitant Use with Disulfiram:
Source: FDA drug label (Fexinidazole), Sanofi-Aventis U.S. LLC, effective May 2, 2025 (SPL set 74a611bc-9977-46bb-b626-0370b3031628), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Disulfiram | Fexinidazole | |
|---|---|---|
| Labeled for | Alcohol use disorder | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.82 per tablet 250 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once